PROTECTIVE EFFECTS OF AQUEOUS LEAF EXTRACT OF CADABA FARINOSA ON HISTOLOGY OF THE GASTROINTESTINAL TRACT OF ADULT WISTAR RATS

Abstract

Protective effects of phytochemicals offer notable prospects in exploring new therapeutics. Herbs are effective treatments of Peptic ulcer diseases than synthetic drugs. Most synthetic drugs cause adverse effects including impotence and hematopoietic disorders on chronic usage. Current treatments mainly targets potentiation defensive system of gastrointestinal tract with lowering acid secretion. Cadaba farinosa is a flowering plant in the Capparidecae family with high ethno-medicinal value, referred as ‘mucosae plant medicine’. Traditionally, it’s used for treatments of diarrhoea, dysentery and intestinal helminthes. This study investigated cytoprotective effects of oral administration of aqueous leaf extracts. Sixteen adult Wistar rats were divided into four groups of four rats. Group 1 is control. Extract administered to groups (2, 3 and 4) at 100, 200 and 300 mg/kg, showed increased goblet cells secreting mucus; a major lining epithelia vulnerable to cellular compartment. Hence, phytochemicals offers notable prospect for exploring new therapeutics