ANDROGENIC PROFILES INHIV-INFECTED MALE PATIENTS ON HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY: COULD THIS BE A THREAT TOFERTILITY? SHORT COMMUNICATION

Abstract

Background:This study aimed to evaluate the Serum Androgenic Profilesof HIV-infected Male Patients on Highly Active Antiretroviral Therapy and those not onActive Antiretroviral Therapyin Specialist Hospital Sokoto, Nigeria. Materials and Methods: One hundred and thirty-five HIV infected male patients were evaluated in the Departmentof Medicine, Specialist Hospital Sokoto Nigeria from July 2017 to March 2018 using history, baseline investigations, and CD4counts. Free testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) were measured using an overnight fasting serum sample. Patients were divided into three groups (n=45); Group A= HIV-infected male patients on HAART, Group B = HIV- infected male treatment naive patients, and Group C= HIV-negative control subjects. Data were analysedusing ANOVA and Chi square tests and p≤ 0.05 was considered statistically significant Results:The serum testosterone and CD4 counts were reducedin HIV-infected male patients on HAART and HAART naive compared to the negative control. The reduced testicular functions were substantiated by raised serum LH and FSH in HIV-infected male patients on HAART (p < 0.05) compared to the negative control. Conclusions:HIV infections associated with low CD4 counts even among patients on Highly Active Antiretroviral Therapymay pose threat to male fertility