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dc.contributor.authorAnzaku, SA-
dc.date.accessioned2024-05-27T17:53:14Z-
dc.date.available2024-05-27T17:53:14Z-
dc.date.issued2019-12-10-
dc.identifier.issn0932-0067-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/1445-
dc.description.abstractBackground Subclinical beta-cell (β-cell) dysfunction is an endocrine abnormality and its association with recurrent miscarriages (RM) has not been extensively studied. Objective This study aimed to determine the prevalence of β-cell dysfunction and abnormal glucose metabolism [fasting blood glucose (FBG) ≥ 5.1 mmol/L] among non-diabetic women with recurrent miscarriages and to establish if there was an association between RM and β-cell dysfunction and FBG ≥ 5.1 mmol/L. Methodology This was a cross-sectional study involving 80 women with miscarriages at ≤ 13 weeks gestation and 80 women with normal pregnancies at ≤ 13 weeks of gestation with at least one successful live-birth and no history of miscarriage (comparison group). Interviewer-administered questionnaire was used to obtain relevant information. From each participant, FBG and fasting insulin were assayed. β-Cell function was computed. The data obtained was analysed using IBM-SPSS version 22.0. Results A significantly higher prevalence of β-cell dysfunction and abnormal glucose metabolism were observed among non-diabetic women with RM compared to age-matched controls (38.8% vs 10.0%, P < 0.001) and (27.5% vs 6.3%, P = 0.005) respectively. The mean β-cell function of the cases was 59.0% of the controls (264.41 ± 105.13 vs 447.82 ± 181.24, P < 0.001). Mean FBG was significantly higher in the case-group compared to the controls (4.77 ± 1.14 mmol/L vs 3.58 ± 0.78 mmol/L, P < 0.001). There was a significant association between RM and FBG ≥ 5.1 mmol/L and low β-cell function (P < 0.001). Conclusion This study suggests that women with recurrent miscarriages are more likely to have impaired β-cell function and abnormal glucose metabolism (FBG ≥ 5.1 mmol/L).en_US
dc.description.sponsorshipAdikpe Emmanuel Edugbe1 · Bitrus James1 · Uche Augustine Akunaeziri2 · Christopher Orokpo Egbodo3 · Chidiebere Lucius Imoh4 · Anzaku Stephen Ajen1 · Onyeji John1 · Mikah Samaila1en_US
dc.language.isoen_USen_US
dc.publisherArchives for Gynecology and Obstetricsen_US
dc.subjectβ-Cell dysfunction · Abnormal glucose metabolism · Recurrent miscarriagesen_US
dc.titleBeta-cell dysfunction and abnormal glucose metabolism among non-diabetic women with recurrent miscarriagesen_US
dc.typeArticleen_US
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