WOUND HEALING PROPERTIES OF CHROMOLAENAODORATAEXTRACT CREAM

Abstract

In many Nigerian and other African cultures, medicinal plants andherbs have been utilized in folklore medicine for wound healing and are largely preferred due to their effectiveness, limited toxicity, widespread availabilityand affordability. . This study isaimedat adding value to the wound healing effectiveness of Chromolaenaodorata as claimed in the folkloric medicine. The bioactive compounds from Chromolaenaodorata leaves were extracted using methanoliccold maceration.Thereafter, an oil-in-water herbal cream was formulated by incorporating the Chromolaenaodorata extract into an Oleaginous base at two different extract concentrations – 5%w/w cream (5% CO Cream) and 7%w/w cream (7% CO Cream). The physiochemical properties as well as the wound healing effects of the creams were evaluated.Both herbal cream formulations had dark green colour, good homogeneity, smooth consistency, and good stability. They also showed no allergic reaction following skin irritation test and had excellent wash-ability. The wound healing effect is concentration dependent; the 7%CO Cream decreased the incised wound surface area faster than the 5%CO Cream. The 7%CO Cream was also more effective than the comparator,Sudo-Cream (positive control).