Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/2903
Full metadata record
DC FieldValueLanguage
dc.contributor.authorADOGA, Godwin-
dc.date.accessioned2024-09-26T13:09:10Z-
dc.date.available2024-09-26T13:09:10Z-
dc.date.issued2017-03-
dc.identifier.citationJawonisi, I., & Adoga, G. (2017). Acute toxicity, haematological and histopathological assessment of the ethanolic extract of Lantana camara leaf. Journal of Pharmacy & Bioresources, 14(1), 45-50.en_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/2903-
dc.description.abstractLantana camara is a noxious weed. This study was conducted to investigate the acute toxicity of the ethanol macerate of Lantana camara Linn. leaf in albino rats. Assessment of haematological and histological parameters of major organs following administration of the extract was undertaken. Lorke’s method was used for the acute oral toxicity testing. Haematological parameters; whole and differential blood cell counts were determined using automated haematology analyzer. Histological examination of major organs was done using John D Bancroft manual method. The LD50 was found to be greater than 5,000 mg/kg body weight of the rats. The white blood cells, red blood cells, haemoglobin, packed cell volume, platelet, and differential cell counts of the albino rats were found to be within normal ranges for rats. Histological organization of the kidney and liver of treated rats at high doses showed structural changes typical of adaptive responses to pathologic stimuli. The results from this study suggest that the seventy percent ethanol macerate of L. camara Linn. leaf can be used with some degree of safety for short period of time via oral routeen_US
dc.publisherJornal of Pharmacy and Bioresourcesen_US
dc.subjectLantana camaraen_US
dc.subjectPathologic stimulien_US
dc.subjectToxicityen_US
dc.titleAcute toxicity, haematological and histopathological assessment of the ethanolic extract of Lantana camara leafen_US
dc.typeArticleen_US
Appears in Collections:Research Articles



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.