The Pharmacological Evaluation of Cold Water Stem-Bark Extract of Erythrophleum suaveolens on Gastrointestinal Muscle of Guinea-Pig (Cavia porcellus) Ileum

Abstract

The effect of cold water crude extract of stem-bark of Erythrophleum suaveolens on the activity of an isolated guinea-pig Ileum was studied. Reference drugs (Acetylcholine, Histamine, Barium Chloride, Atropine, Promethazine, and Papaverine) were used both in the presence and absence of E. suaveolens extract. Preliminary pharmacological investigation of the extract revealed inhibitory effects. Thus, investigations carried out on the isolated ileum tissue of the guinea-pig (Cavia porcellus) by running a dose-response relationship of the agonist test drugs (Acetylcholine, Histamine, and Barium Chloride) in the presence of the cold water crude extract of stem-bark of Erythrophleum suaveolens ascertained antagonist nature of the extract with a right shift. However, the degree of shift in presence of Barium Chloride is less than that with Histamine and Acetylcholine respectively.