Abstract:
Th coronavirus disease 2019 (COVID-19) pandemic is signifiantly causing unprecedented
clinical, socioeconomic, and public health challenges globally. The successful global
administration of effctive, safe and sustainable vaccine(s) is widely believed to be crucial
in mitigating as well as preventing COVID-19. However, the rising cases of severe adverse
events following immunization (AEFI) with COVID-19 vaccines including thrombosis,
thrombocytopenia, and in some instances, death have created serious global concerns
and could enormously contribute to vaccine hesitancy. Although the complete underlying
pathophysiology and immunopathology of the COVID-19 vaccines related to AEFI,
including thrombosis and/or anaphylaxis, are yet to be determined, exploring possible
immuno-hypersensitivity could be crucial in the mechanisms associated with these reactions,
thereby mitigating their occurrences as well as restoring confience in vaccine administration
for a COVID-19 free world.
