Abstract:
Abstract: Mosquito repellents are used extensively in Nigeria to prevent mosquito
and diseases associated with them. Most active constituents of repellents are well
known for their toxicities. The purpose of this study was to determine the
nephrotoxic effects of Rambo and Sharp mosquito repellents commonly used in
Sokoto State, Nigeria. Exposure of 27 Wistar rats to Rambo and Sharp mosquito
repellents for 5 min per day over a period of 21 days induced interstitial
haemorrhage, glomerular and tubular degenerations. Glomerular damage is
characterized by shrunken glomeruli and widening of bowman space. Sharp
repellent containing 70% dichlorvos was the most injurious insecticide. Therefore,
repeated exposures to mosquito repellents are deleterious to the kidney.
