Abstract:
Background:This study aimed to evaluate the Serum Androgenic Profilesof HIV-infected
Male Patients on Highly Active Antiretroviral Therapy and those not onActive
Antiretroviral Therapyin Specialist Hospital Sokoto, Nigeria.
Materials and Methods: One hundred and thirty-five HIV infected male patients were
evaluated in the Departmentof Medicine, Specialist Hospital Sokoto Nigeria from July
2017 to March 2018 using history, baseline investigations, and CD4counts. Free
testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) were
measured using an overnight fasting serum sample. Patients were divided into three
groups (n=45); Group A= HIV-infected male patients on HAART, Group B = HIV-
infected male treatment naive patients, and Group C= HIV-negative control subjects. Data
were analysedusing ANOVA and Chi square tests and p≤ 0.05 was considered
statistically significant
Results:The serum testosterone and CD4 counts were reducedin HIV-infected male
patients on HAART and HAART naive compared to the negative control. The reduced
testicular functions were substantiated by raised serum LH and FSH in HIV-infected male
patients on HAART (p < 0.05) compared to the negative control.
Conclusions:HIV infections associated with low CD4 counts even among patients on
Highly Active Antiretroviral Therapymay pose threat to male fertility
