Abstract:
Infertility is one of the major health problems of reproductive age
couples. The suggestion that oestrogen beta receptor polymorphism
has unfavorable effects on the male fertility is contentious. This
review study aimed to identify the impact of estrogen beta receptor
polymorphism on male infertility. The comprehensive literature
review focused on the role of estrogen beta receptor (ERβ) in the
testis, its effects on sperm motility, longevity, and fertilizing capacity,
as well as the relationship between ERβ mutation and male infertility.
The review highlighted the critical role of ERβ in sperm function,
emphasizing its strong expression in the testis and its significance for
sperm motility and fertilizing capacity. The absence of ERβ was
found to diminish epididymal sperm content, sperm motility, and
fertility, thereby contributing to male infertility. Additionally, the
review discussed the influence of environmental, physiological, and
genetic factors on male factor infertility and emphasized the need
for further molecular studies to determine the implications of ERβ
mutation in a multifactorial manner.
The literature cited in the review provided insights into the
prevalence of male infertility worldwide, with a focus on the African
region, where male factor infertility was found to account for a
significant percentage of infertility cases. Genetic evaluations and
lifestyle changes, including the inclusion of antioxidant vitamins and
minerals in treatment regimens to prevent oxidative DNA damage
linked to estrogen-induced effects on male reproduction, were
recommended. Furthermore, healthy lifestyle choices and the
avoidance of tobacco smoking, marijuana, and alcohol use may play
central role in preserving male fertility.
