Abstract:
Breast cancer is the leading cause of cancer related deaths worldwide. The development of new blood vessel from
preexisting vasculature is associated to the growth and metastasis of breast cancer. The present review aimed to
highlight the mechanisms of angiogenesis and the progression of malignancy in breast cancer. Poor breast cancer
prognosis correlate with increased micro-vascular density and factors that stimulate vascular growth. Inhibiting
angiogenesis of this process reduce the oxygen and nutrient supply. Therefore, tumor angiogenesis is a strategic
therapeutic target for preventing breast cancer. We suggest the use of angiogenesis inhibitors to be explored to
interrupt the process of tumor development.
