Abstract:
Background: Aluminum phosphide is becoming a very common agent for self-poisoning. The lack of specific antidote
for phosphide poisoning has aroused the current interest of research.
Objectives: This study aimed to investigate the possible protective effect of Vitamin C and D in phosphine-induced
hepatotoxicity in Wistar rats.
Methods: In this experimental study, 20 Wistar rats were randomly divided into five groups ( n = 12). Group I was
apparently normal Control Group. Groups II-V were induced with 2.5 mg/kg ALP. Groups II was without further
treatment while Groups III-IV received vitamin C at 100mg/kg/bw and vitamin D at 10mg/kg/bw. Group V was co-
administered with vitamin C at 100mg/kg/bw and vitamin at 10mg/kg/bw. The treatments lasted for 28 days.
Results: The results showed that Vitamin C and D (P<0.05) increased antioxidant capacity. Combined active
constituents of the Vitamin C and Vitamin D raised the GPX antioxidant activities when compared to the phosphine
poisoned group treated individually with Vitamin C and D. The combined activities of Vitamin C and Vitamin D showed
the highest antioxidant effect as compared with the control
Conclusion: The combined activities of Vitamin C and D supplementation improved the antioxidant defense system
and histology of the liver in phosphine poisoning.
