Abstract:
Background: Indomethacin has analgesic and anƟpyreƟc
properƟes. It is a common treatment for pain and
rheumatoid diseases, but it has many side effects. We
speculate that the natural anƟoxidants of Moringa oleifera
could be a remedy for the long list of side effects. This
study aimed to determine the possible protecƟve effect of
Moringa oleifera leaf extract on the indomethacin-induced
degenerated testes and uterus in albino rat.
Methods: Forty-eight white albino rats were assigned
randomly into six groups consisƟng of eight rats. Group,
I was the Normal control. Group II was animals induced with
indomethacin but not treated. Group III was dosed with 500
mg/kg Moringa oleifera leaf extract while Groups IV-VI were
induced with indomethacin and treated with 100, 250, and
500 mg/kg Moringa oleifera leaf extract respecƟvely for 28
days. Animals were euthanized aŌer the treatment period.
The uterus and testes were excised and processed using
the paraffin wax method and stained with haematoxylin and
eosin.Results: Animals exposed to indomethacin became
drowsy and lethargic with deep red teary eyes. The first
mortality was recorded among animals administered with
indomethacin without treatment. Histopathology of the
testes showed that indomethacin caused degeneraƟon of
the seminiferous tubules and diminished the spermatozoa.
The histology of the uterus was distorted, the endometrium
and myometrium layers of the uterus were disintegrated.
However, animals treated with Moringa oleifera showed
dose-related improvements in the histology of the testes and
uterus compared to the control group.
Conclusion: Moringa oleifera leaf extract improved the
histology of indomethacin-induced toxicity of the testes anduterine in white albino rats.
