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Preparation and Characterization of Crosslinked Starch-Albumin Films for Coating of Prednisolone Tablets for use in Covid-19 Related Respiratory Disease

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dc.contributor.author ALFA, John
dc.date.accessioned 2024-05-31T10:15:35Z
dc.date.available 2024-05-31T10:15:35Z
dc.date.issued 2022-12
dc.identifier.issn 2636–5448
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/1564
dc.description.abstract Steroidal products have been found useful in inflammations associated with Covid 19. Prednisolone is one readily available steroid, which is often found as uncoated normal release tablets. Modified release prednisolone may be desirable in Covid 19 for sustained actions. This is expected to reduce dosing frequency and enhance compliance. This study is concerned with development of controlled release prednisolone using coating technology with bio-compatible, cross-linked starch-albumin films. Starches and proteins are excellent film formers with good flexibility, transparency, and bio-compatibility. The cross-linked starch-albumin films were prepared using glycerol as the plasticizer: starch (A), starch-albumin (B), starch-albumin cross-linked with formaldehyde at 1 % (C), 5 % (D) and 10 % (E). Equilibrium moisture sorption (EMS) at 100 % relative humidity, equilibrium swelling (ESC) in buffer solutions of pHs 2, 7 and 9, and DSC thermal properties were evaluated. In-vitro drug release from the film coated prednisolone tablets were evaluated in 0.1N HCl, water and phosphate buffer 8.0 as dissolution media. Films showed ESC in the order A>D>E>B>C; D>C>A>E>B and A>D>C>B>E in acidic, neutral and alkali media respectively. EMS was in the order B>E>A>D>C; with slight shift in the melting temperatures. In-vitro release at 240 min varied from 78 to 117 % (E>D>C>A>B); 19 to 60 % (D>B>C>E>A) and 49 to 60 % (B>A>C>D>E) in 0.1N HCl, water and PBS respectively. Cross-linking improved the stability and swelling of films. The in-vitro release in alkaline medium suggests their usefulness for controlled drug delivery. New pH-responsive polymers, with improved physicochemical properties for coating prednisolone tablets were developed. en_US
dc.publisher Journal of Phytomedicine and Therapeutics en_US
dc.relation.ispartofseries Volume 21;No. 2
dc.subject Starch en_US
dc.subject serum-albumin en_US
dc.subject films en_US
dc.subject cross-linking en_US
dc.subject Prednisolone en_US
dc.subject COVID-19 en_US
dc.title Preparation and Characterization of Crosslinked Starch-Albumin Films for Coating of Prednisolone Tablets for use in Covid-19 Related Respiratory Disease en_US
dc.type Article en_US


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