Abstract:
Several literatures exist on the efficacy of Cyphostemma glaucophilla. in the treatment of
diverse ailment ranging from malnutrition disorders to systemic diseases such as hypertension and
kidney problems. Effect of aqueous leave extract of Cyphostemma glaucophilla. was investigated
on Carbon tetrachloride induced hepatotoxicity by evaluating its biochemical activities on Aspartate
Amino Transferase (AST), Alanine Amino Transferase (ALT). Alkaline Phosphatase (ALP),
Bilirubin and creatinine. The negative control group A were served daily doses of saline (0.85%
NaCl; 5 mL kg-1) positive control group B received (0.85% NaCl?5 mL kg-1 and a single
concentration 5 mL kg-1 of CC14) while groups C, D, E and F were given 5.0, 10.0, 15.0,
20.0 mg kg-1 body weight of extract using stomach tubes for 7 days, respectively. CCl4 (5 mL kg-1)
single concentration was administered to groups B, C, D, E and F on the 8th day however, extract
administration continued for groups C, D, E and F on day 9 and 10. The activities of the enzyme
markers in the positive control group were observed to increase significantly (p<0.05) when
compared with the negative control and the test groups C, D, E and F. The test groups administered
varying doses of extract after exposure to CC14 decreased significantly (p<0.05) and in a dose
dependent manner the activities of ALT, AST and ALP. There was also a significant (p<0.05) dose
dependent decrease in the level of unconjugated, conjugated bilirubin and creatinine. It is
observed, that Cyphostemma glaucophilla among its numerous pharmacological properties may
serve as a cheap alternative in maintaining liver and kidney disorders
