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Browsing Department of Pharmacology & Toxicology by Issue Date

Browsing Department of Pharmacology & Toxicology by Issue Date

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  • Preparation and Evaluation of Mucinated Sodium Alginate Microparticles for Oral Delivery of Insulin 
    BUILDERS, Philip F.; KUNLE, Olobayo O.; OKPAKU, Larry C.; BUILDERS, Modupe I.; ATTAMA, Anthony A.; ADIKWU, Michael U. (EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (EJPB) Vol. 70, 2008)
    Effective oral insulin delivery remains a challenge to the pharmaceutical industry. In this study, insulinloaded microparticles for oral delivery were prepared with mucin and sodium alginate combined at different ratios ...
  • Assessment of the Intrinsic and Stability Properties of the Freeze-Dried and Formulated Extract of Hibiscus Sabdariffa Linn. (Malvaceae) 
    BUILDERS, Philip F.; EZEOBI, Chukwuemeka R.; TARFA, Florence D.; BUILDERS, Modupe I. (AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY (AJPP) Vol. 4 No. 6, 2010-06)
    Water extract of the calyces of Hibiscus sabdariffa Linn (Malvaceae) is used widely as a food additive and refreshing drink with proven medicinal benefits, which are attributed to its phytochemical constituents. Relevant ...
  • Antiplasmodial Activities of Parkia Biglobosa Leaves: In Vivo and In Vitro Studies 
    BUILDERS, Modupe I.; WANNANG, Noel; AGUIYI, John (ANNALS OF BIOLOGICAL RESEARCH (ABR) Vol. 2 No. 4, 2011)
    The wide spread resistance of malaria parasites to conventional anti-malarials have stimulated the search for new drug entities especially those with new modes of action. The efficacy of the preparations of Parkia biglobosa ...
  • Prescription Patterns of Analgesics in a Community Hospital in Nsukka 
    BUILDERS, Modupe I.; OKONTA, J. M.; AGUWA, C. N. (JOURNAL OF PHARMACUETICAL SCIENCE AND RESEARCH (JPSR) Vol. 3 No. 12, 2011)
    Analgesics are one of the most prescribed groups of drugs. Faulty prescription patterns in analgesics often results in aggravated side effects and drug interactions leading to serious adverse drug reactions. In this study ...
  • Patients’ Attitudes Towards Analgesic Usage in Nsukka Community 
    BUILDERS, Modupe I.; AGUWA, Cletus Nze (SCHOLARS RESEARCH LIBRARY (SRL) Vol. 4 No. 2, 2012)
    Analgesics, though relatively safe, are among the commonly used and abused drugs. Many people concomitantly take the same analgesics of different brands thereby contributing to analgesic nephropathy. In this study we ...
  • Toxicity Studies of the Extracts of Parkia Biglobosa Stem Bark in Rats 
    BUILDERS, Modupe I.; ISICHIE, C. O.; AGUIYI, J. C. (BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH (BJPR) Vol. 2 No. 1, 2012)
    Extracts of Parkia biglobosa stem bark is used in Nigerian traditional medicine (NTM) to treat malaria, diarrhea and pains. To establish the toxicity profile of the medicine such parameters as the lethal dose (LD50) as ...
  • Antiplasmodial Potential of the African Mistletoe: Agelanthus dodoneifolius Polh and Wiens 
    BUILDERS, Modupe I.; UGURU, M. O.; AGUIYI, C. (INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (IJPS) Vol. 74 No. 3, 2012-06)
    Preparations of Agelanthus dodoneifolius have been used in the traditional Nigerian medicine to treat malaria and this practice has remained till date without scientific validation. The antiplasmodial property of the water ...
  • Assessment of Antimalarial Drug Use among the Patients in a Tertiary Hospital in Northern Part of Nigeria 
    BUILDERS, Modupe I.; OGBOLE, Emmanuel; PETER, Jonah Y. (INTERNATIONAL JOURNAL OF TROPICAL DISEASE & HEALTH (IJTDH) Vol. 3 No. 4, 2013)
    Aims: To assess the pattern of antimalarial drug use among the patients attending the teaching hospital in Jos North local Government of Nigeria. Study Design: Cross-sectional study. Place and Duration of Study: Tertiary ...
  • Antimalarial Drugs: A Review 
    BUILDERS, Modupe I. (INTERNATIONAL JOURNAL OF PHARMACY (IJP) Vol. 3 No. 1, 2013)
    Malaria causes about 400-900 million cases of fever and approximately 1-3 million deaths annually; this represents at least one death every 30 seconds. The vast majority of cases occur in children under the age of 5 years, ...
  • Phytochemical Screening and In vivo Antiplasmodial Sensitivity Study of Locally Cultivated Artemisia annua Leaf Extract Against Plasmodium berghei 
    OGBOLE, Emmanuel. A.; OGBOLE, Yewubdar; PETER, Jonah. Y.; BUILDERS, Modupe. I.; AGUIYI, John. C. (AMERICAN JOURNAL OF ETHNOMEDICINE (AJE) Vol. 1 No. 1, 2014)
    Objective of the study: Medicinal plant research has become very important considering the herbal resources our rain forest is bestowed with which if harnessed could solve the challenges in malaria treatment in the area ...
  • Prescription Pattern of Antimalarial Drugs in a Teaching Hospital in Nigeria 
    BUILDERS, Modupe I.; DEGGE, Hannah; PETER, Jonah Y.; OGBOLE, Emmanuel (BRITISH BIOMEDICAL BULLETIN (BBB) Vol. 2 No. 1, 2014)
    Introduction: As a response to the anti-malarial drug resistance situation, the World Health Organisation (WHO) recommends that treatment policies for falciparum malaria in all countries experiencing resistance to monotherapies ...
  • Moringa Oleifera Ethosomes a Potential Hair Growth Activator: Effect on Rats 
    BUILDERS, P. F.; IWU, I. W.; MBAH, C. C.; BUILDERS, Modupe I.; AUDU M. M., M. M. (JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL SCIENCES (JPBS) Vol. 4 No. 7, 2014)
    The hair growth promoting activity of Moringa oleifera leaf extract formulated as an ethosome (MOE) had been investigated. The skin irritation test evaluated in terms of erythema and edema. Five groups of five rats each ...
  • Pattern of hospitalization in Bingham University Teaching Hospital 
    BUILDERS, Modupe I.; AKANDE, P.; RAMYIL, M. S.; OGUNDEKO, T. O. (THE PHARMA INNOVATION JOURNAL (TPIJ) Vol. 3 No. 4., 2014)
    A retrospective study was carried out to assess the pattern of hospital admission in a teaching hospital; to determine the frequency of the most common diagnoses and the medication prescribe during admission. 1099 male and ...
  • Parkia Biglobosa (African Locust Bean Tree) 
    BUILDERS, Modupe I. (WORLD JOURNAL OF PHARMACEUTICAL RESEARCH (WJPR) Vol. 3 No. 2, 2014)
    P. biglobosa (Jacq.) R.Br. ex G. Don (family fabaceae) popularly called the African locust bean tree have been used traditionally as food and medicine and are of high commercial value in the West African region. The plant ...
  • Acute toxicity studies of locally cultivated Artemisia annua leaf extract in Rats 
    OGBOLE, Emmanuel Anebi; ISAIAH, Idyu; OGUNDEKO, Timothy; ASALU, Adedayo F.; BUILDERS, Modupe I.; AGUIYI, John (WORLD JOURNAL OF PHARMACEUTICAL SCIENCES (WJPS) Vol. 2 No. 12, 2014)
    Artemisia annua is a medicinal plant native to China and well known for its antiplasmodial, antirheumatic and anticancer properties. The acute toxicity, phytochemical screening and elemental analysis of hexane extract of ...
  • Acute Toxicity Studies of Erythrophleum suaveolens in Albino Mice (Mus musculus) 
    IDYU, I. I.; KELA, S. L.; IDYU, V. C.; AKINYEDE, A.; BUILDERS, Modupe I.; OGBOLE E A., A.; RAMYIL, M. S.; OGUNDEKO, T. O. (INTERNATIONAL JOURNAL OF SCIENCE AND RESEARCH (IJSR) Vol. 3 No. 4, 2014-04)
    The activity of crude hydro-extract of stem bark of Erythrophleum suaveolens against Albino Mice was investigated. Extracted doses (50-300mg/kg) of the crude extract were administered. No mortality was recorded at low doses ...
  • The Pharmacological Evaluation of Cold Water Stem-Bark Extract of Erythrophleum suaveolens on Gastrointestinal Muscle of Guinea-Pig (Cavia porcellus) Ileum 
    IDYU, I. I.; OLAOYE, T. O.; SOKOMBA, E. N.; IDYU, V. C.; RAMYIL, M. S.; OGBOLE, E. A.; BUILDERS, Modupe I.; OGUNDEKO, T. O. (INTERNATIONAL JOURNAL OF SCIENCE AND RESEARCH (IJSR) Vol. 3 No. 5, 2014-05)
    The effect of cold water crude extract of stem-bark of Erythrophleum suaveolens on the activity of an isolated guinea-pig Ileum was studied. Reference drugs (Acetylcholine, Histamine, Barium Chloride, Atropine, Promethazine, ...
  • Antimalarial Activity and Isolation of Phenolic Compound from Parkia biglobosa 
    BUILDERS, Modupe I.; ALEMIKA, Taiwo; AGUIYI, John (JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCES (JPBS) Vol. 9 No. 3, 2014-06)
    Parkia biglobosa popularly called African locust bean tree is used traditionally for the treatment of malaria. Phenolic compounds were found to be the major antimalarial components of Parkia biglobosa .The aim of this work ...
  • Investigation of Relaxative Effect of Stem-Bark Extract of Erythrophleum Suaveolens on Rat Phrenic Nerve-Diaphragm Muscle 
    OGUNDEKO, T. O.; IDYU, I. I.; OJO, M. T.; IDYU, V. C.; OGBOLE, E. A.; BUILDERS, Modupe I. (JOURNAL OF ADVANCES IN MEDICAL AND PHARMACEUTICAL SCIENCES (JAMPS) Vol. 3 No. 1, 2015)
    Background: The effect of crude extract of Erythrophleum suaveolens was studied on isolated tissues of the Rat’s phrenic nerve-diaphragm muscles. Study aimed to investigate the relaxant effect of crude extract of E. ...
  • Plants as Antimalarial Drugs: A Review 
    BUILDERS, Modupe I. (WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (WJPPS) Vol 4 No. 8, 2015)
    Malaria is a protozoa disease, transmitted by the Anopheles species of mosquito carrying the Plasmodium parasite. Despite the substantial progress made in the treatment of parasitic diseases, malaria remains a significant ...

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