Abstract:
Abstract
Introduction Continuous ambulatory peritoneal dialysis
(CAPD) is the ideal modality for renal replacement
therapy in most African settings given that it is relatively
cheaper than haemodialysis (HD) and does not require
in-centre care. CAPD is, however, not readily utilised as it
is often complicated by peritonitis leading to high rates of
technique failure. The objective of this study is to assess
the prevalence of CAPD-related peritonitis and all-cause
mortality in patients treated with CAPD in Africa.
Methods and analysis We will search PubMed, EMBASE,
SCOPUS, Africa Journal Online and Google Scholar for
studies conducted in Africa from 1 January 1980 to 30
June 2017 with no language restrictions. Eligible studies
will include cross-sectional, prospective observational and
cohort studies of patients treated with CAPD. Two authors
will independently screen, select studies, extract data
and conduct risk of bias assessment. Data consistently
reported across studies will be pooled using random effects meta-analysis. Heterogeneity will be evaluated
using Cochrane’s Q statistic and quantified using I2
statistics. Graphical and formal statistical tests will be
used to assess for publication bias.
Ethics and dissemination Ethical approval will not be
needed for this study as data used will be extracted from
already published studies. Results of this review will be
published in a peer-reviewed journal and presented at
conferences. The Preferred Reporting Items for Systematic
reviews and Meta-Analyses for Protocols 2015 (PRISMA-P
2015) framework guided the development of this protocol.
PROSPERO registration number CRD42017072966.
