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Cocos nucifera L. oil alleviates lead acetateinduced reproductive toxicity in sexually-matured male Wistar rats

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dc.contributor.author OKOLI, B.J
dc.date.accessioned 2024-06-24T23:38:51Z
dc.date.available 2024-06-24T23:38:51Z
dc.date.issued 2021-03-15
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/2290
dc.description.abstract Objectives: Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetateinduced reproductive toxicity in male Wistar rats. Methods: Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III— 6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results: The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions: Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties. en_US
dc.publisher J Basic Clin Physiol Pharmacol en_US
dc.subject Cocos nucifera oil en_US
dc.subject lead acetate en_US
dc.subject reproductive system en_US
dc.subject Wistar rats. en_US
dc.title Cocos nucifera L. oil alleviates lead acetateinduced reproductive toxicity in sexually-matured male Wistar rats en_US
dc.type Article en_US


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