Abstract:
The study was done with the aim to evaluate the anthelmintic
activity of curcin from Jatropha curcas seed using adult
earthworm Pheritima posthuma against Niclosamide (5 mg/mL) as
standard references and normal saline as control. The activities of
the possible crude curcin was determined on the tested parasites
in this study so as to verify if the Jatropha curcas seed would be a
potential sources of useful anthelminthic drugs by monitoring the
time to achieve paralysis of the worms was determined. In the
acute toxicity test, toxic signs were observed at 300mg/kg.
However, the Pheritima posthuma displayed physical changes with
LD50 of 800mg/kg per body weight. The toxicity of curcin in
Pheritima posthuma is high; however, caution should be exercised
in its use especially at high doses.
