Abstract:
Background: Prior to commencing antiretroviral therapy (ART), haematological abnormalities are a common occurrence
in individuals diagnosed with human immunodeficiency virus (HIV). In the course of receiving ART, these abnormalities
usually improve. We determined the prevalence of haematological abnormalities in children diagnosed with HIV-1 and
the changes in haematological parameters that occur after 6 and 12 months of being on ART.
Methods: A cross-sectional study of HIV-1 infected children aged 2 months to 15 years, between July 2005 and March
2013, at the paediatric HIV clinic of the Jos University Teaching Hospital, Jos. Median values of repeated measures were
compared using the Wilcoxon signed-rank sum test.
Results: The prevalence of anaemia, thrombocytopenia and leukopenia among the 941 children studied, prior to ART
was 6.4%, 7.0% and 8.6%. Median (IQR) haemoglobin (Hb) levels increased from 10 g/dL (9–11 g/dL) at baseline to
11 g/dL (10–12 g/dL) and 11 g/dL (10–12 g/dL) at 6 and 12 months of ART (P<0.001 and P<0.001), respectively, a
10% increase in both cases. Also, platelet count increased from a median of 327×103/μL (243–426×103/μL) at baseline
to 333×103/μL (266–408×103/μL) at 6 months and 339×103/μL (267–420×103/μL) at 12 months, representing a 1.8%
and 3.7% increase, respectively. The median total white blood cell count decreased from 7.4×103/μL (5.3–9.9×103/μL)
at baseline to 5.9×103/μL (4.6–8.0×103/μL) and 5.8×103/μL (4.5–7.5×103/μL) at 6 and 12 months of ART (P<0.001
and P<0.001), a 20.3% and 21.6% decrease, respectively.
Conclusion: During the 12 months of ART, children in our cohort had significant improvements in haematological parameters
such as haemoglobin levels and platelet counts, which would suggest an early positive response to ART.
