Abstract:
Background - Worldwide, tuberculosis (TB) is one of the top 10 causes of death. Drug resistant tuberculosis has lately become
a major public health problem that threatens progress made in Tuberculosis (TB) care and control worldwide. The aim of this
study was to determine the prevalence of Pre-extensive drug resistant TB among MDR TB in North Central of Nigeria.
Methods - This study was conducted from October, 2018 to August, 2019 with 150 samples. In Nigeria, guidelines for DR-TB
as recommended by WHO is followed. All the samples from the patients who gave their consent were transported to a zonal
reference TB laboratory (ZRL).
Results - Mean age was 38.6 ± 13.4 years with peak age at 35-44. Out of these 103 samples processed with LPA, 101(98%) were
rifampicin resistant and 2 were rifampicin sensitive, 99(96%) were INH resistant and 4 (4%) were INH sensitive, 5(5%) were
fluoroquinolone resistant, 98(95%) were fluoroquinolone sensitive, 12 (12%) were Aminoglycoside + Capreomycin resistant,
91(83%) were Aminoglycoside + Capreomycin sensitive.
Conclusion - Multidrug resistant TB and its severe forms (Pre-extensive & extensively drug resistant TB) can be detected early
with rapid tool- Line Probe Assay rapid and prevented timely by early initiation on treatment.
