Abstract:
Background: The World Health Organization (WHO) recommends the use of Isoniazid
Preventive Therapy (IPT) among People Living with HIV (PLHIV) to reduce morbidity and
mortality from Tuberculosis (TB). This study assessed the rate of IPT completion and its
associated factors among PLHIV in South West Nigeria.
Methods: A review of records of 1526 PLHIV who commenced IPT between October 2017
and December 2018 was done. Data were extracted from facility level IPT service
documentation tools using study-developed data abstraction template. The chi-square
test was used to assess the association between the independent variables and the
patient’s IPT completion status at 0.05 significance level. Logistic regression was used to
determine the predictors of IPT completion.
Results: The mean age of the study population was 42.3±11.3 years and 1154 (75.6%) of
them were females. About 1342 (87.9%) completed IPT within six months of initiation.
Major reasons for non-completion of IPT were lost to follow up 86 (46.7%) and nonadherence
to IPT 60 (32.6%). Higher proportion of respondents who were Igbo (92.9%),
ART-naïve (97.6%) or active on ART regimen (94.8%) completed their IPT regimen within
6 months of initiation when compared to those of other tribes (p=0.023), ART experienced
(87.7%), (p=0.023) or inactive on treatment (0.9%), (p<0.001) respectively.
Traders/farmers were 6 times more likely to complete IPT compared to public/civil
servants (AOR=6.110, 95%CI=2.180-17.112, p=0.001).
Conclusion: IPT completion rate was high among study participants. Intensified
counselling on IPT benefits among ART patients with focus on civil/public servants might
further improve IPT completion.
