Abstract:
Background: The prevalence and usefulness of MetS in determining CVD risk in at-risk populations are influenced by
its definition. In a cohort of HIV-positive Nigerians, we evaluated MetS based on yarious defining criteria, their agreement
with one another, arid their association to a CVD endpoint, Carotid-Intimal-Media-Thickness (CIMT).
Methodology: In this cross-sectional study, 145 HIV-positive individuals who [were enrolled in HIV clinics at the Faith
Alive Foundation and Jos University Teaching Hospital in Jos, Nigeria, Were randomly chosen. Biophysical and
anthropometric measurements including blood pressure, height, weight, waist circumference, and hip-circumference, as
well as clinical records, CIMT, fasting plasma glucose, and lipid profile, were assessed.
Result: The median (Interquartile range) age of the participants was 41 (35-88) years, and the majority (71.7%) were
females. The prevalence of metabolic syndrome (MetS) by the Adult Treatment Panel-IH (ATP), International Diabetes
Federation (IDF), and Joint Interim Statement (JIS) criteria were 30.3%, 32.4%, and 35.2% respectively. MetS by all
criteria was more prevalent among females and. participants >“40.years, p<0.05. 'Low HDLc (93.6-95.5%), Central obesity
(86.3-95.5%), and hypertension (80.9-86.4%) were the most frequent components of MetS. HIV-related parameters were
not associated with MetS. The overall agreement among MetS criteria was almost perfect between IDF and JJS criteria
(k=0.94); and.strong between IDF vs., ATP (k=0.82) and ATP vs. JIS (k=0.89). There was no significant difference in the
median CIMT in PLHIV. with and without MetS across all defining criteria. j
Conclusion: The prevalence of MetS in PLHIV is relatively high, particularly among females and older individuals. The
correlations between the defining criteria were fairly strong and consistent across.subpopulations of PLHIV. MetS based
