The Pharmacological Evaluation of Cold Water Stem-Bark Extract of Erythrophleum suaveolens on Gastrointestinal Muscle of Guinea-Pig (Cavia porcellus) Ileum

IDYU, I. I.; OLAOYE, T. O.; SOKOMBA, E. N.; IDYU, V. C.; RAMYIL, M. S.; OGBOLE, E. A.; BUILDERS, Modupe I.; OGUNDEKO, T. O.

dc.contributor.author	IDYU, I. I.
dc.contributor.author	OLAOYE, T. O.
dc.contributor.author	SOKOMBA, E. N.
dc.contributor.author	IDYU, V. C.
dc.contributor.author	RAMYIL, M. S.
dc.contributor.author	OGBOLE, E. A.
dc.contributor.author	BUILDERS, Modupe I.
dc.contributor.author	OGUNDEKO, T. O.
dc.date.accessioned	2021-12-10T10:02:03Z
dc.date.available	2021-12-10T10:02:03Z
dc.date.issued	2014-05
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/714
dc.description.abstract	The effect of cold water crude extract of stem-bark of Erythrophleum suaveolens on the activity of an isolated guinea-pig Ileum was studied. Reference drugs (Acetylcholine, Histamine, Barium Chloride, Atropine, Promethazine, and Papaverine) were used both in the presence and absence of E. suaveolens extract. Preliminary pharmacological investigation of the extract revealed inhibitory effects. Thus, investigations carried out on the isolated ileum tissue of the guinea-pig (Cavia porcellus) by running a dose-response relationship of the agonist test drugs (Acetylcholine, Histamine, and Barium Chloride) in the presence of the cold water crude extract of stem-bark of Erythrophleum suaveolens ascertained antagonist nature of the extract with a right shift. However, the degree of shift in presence of Barium Chloride is less than that with Histamine and Acetylcholine respectively.	en_US
dc.publisher	INTERNATIONAL JOURNAL OF SCIENCE AND RESEARCH (IJSR) Vol. 3 No. 5	en_US
dc.subject	Erythrophleum suaveolens	en_US
dc.subject	Blocking/Inhibitory effect	en_US
dc.title	The Pharmacological Evaluation of Cold Water Stem-Bark Extract of Erythrophleum suaveolens on Gastrointestinal Muscle of Guinea-Pig (Cavia porcellus) Ileum	en_US
dc.type	Article	en_US